DeLeon Springs is a census-designated place (CDP) in Volusia County, Florida, United States. The population was 2,614 at the 2010 census. De Leon Springs State Park is located in DeLeon Springs, as is the Strawn Historic Citrus Packing House District.

DeLeon Springs is named for Juan Ponce de León. It was originally called Spring Garden and the name was changed in the late 1800s to attract tourists. The region was developed in 1925 with a hotel/restaurant the DeLeon Spring Inn, later called the Ponce de Leon Springs Hotel, which was expanded into a larger tourist attraction in 1953.